For his whole adult life he's played in the highest stakes games on Earth. When he talks about being willing to 'take the worst hand sometimes' he doesn't mean that you should just start pushing all in any time you flop a gut shot draw. Doyle is famous for his uncanny reading ability. However, a few things should be noted by any reader not wanting to lose half their bankroll in the first hour after digesting the material. The classic chapter, Doyle's No Limit musings is also a must read for serious players.
It's a great book particularly Chip Reese's section on stud. If you're a poker player and you haven't read this book then just remember, all the other players around you have.